The Medications for Addiction Treatment (MAT) Guide – Third Edition is a comprehensive, evidence-based resource tailored specifically for Alaska’s unique needs in combatting the opioid crisis. Published by the Alaska Department of Health and developed in partnership with subject matter experts, including ASAM Chapter President Dr. Sarah Spencer, this guide equips healthcare providers with the tools and insights necessary to deliver effective, compassionate care to individuals struggling with substance use disorders.

In the wake of Alaska’s steep rise in overdose deaths — many due to fentanyl — this guide serves as both a call to actionand a practical handbook for providers across disciplines. Organized into five sections and 29 chapters, it covers everything from foundational treatment frameworks to clinical best practices, emerging medications, and community-specific considerations. Here’s what readers will gain:

✅ A Framework for Action
Section I establishes the urgent need for MAT in Alaska and introduces readers to opioid use disorder (OUD), treatment models, and key regulatory updates. It underscores how MAT—especially Medication for Opioid Use Disorder (MOUD)—saves lives and improves community outcomes.

✅ Clinical Guidance and Best Practices
Section II focuses on frontline strategies for screening, initiating treatment, and stabilizing care. It walks providers through practical steps for integrating MOUD into daily practice, even in rural or resource-limited settings.

✅ Deep Dive on FDA-Approved Medications
Section III details the medications used for opioid treatment—Buprenorphine (including new formulations like Brixadi), Methadone, and Extended-Release Naltrexone—along with their proper applications, dosing considerations, and patient support tips.

✅ A Broader View on Substance Use
Section IV expands the focus beyond opioids to address alcohol, stimulants, sedative-hypnotics, tobacco, cannabis, and novel substances. It offers insights into treating polysubstance use and co-occurring disorders.

✅ Tailored Approaches for Vulnerable Populations
Section V highlights the importance of culturally competent, person-centered care for unique groups such as Alaska Natives, youth, pregnant women, veterans, individuals in the criminal justice system, and the unhoused.

✅ Practical Tools and Resources
Throughout the guide, readers will find sample protocols, staffing models, policy templates, and links to free training, mentorship (like Project ECHO), and implementation support services through the Opioid Response Network.

This guide is more than a manual—it is a movement. Alaska’s strength lies in its collaborative spirit, and this guide reflects that unity by weaving together the wisdom, experiences, and resolve of leaders like Dr. Spencer and many others across the state. Providers are encouraged to download the guide, explore its pages, and take active steps to integrate or expand MAT in their own practice.

Together, we can turn the tide.